➨ Modalert, containing modafinil, is generally considered safe for the liver when taken as prescribed; however, caution is advised for individuals with pre-existing liver conditions. Modafinil is primarily metabolized in the liver, so those with liver impairment may require adjusted doses to avoid potential strain on liver function. While Modalert is not typically associated with severe liver toxicity, rare side effects affecting liver enzymes have been reported. It is essential to consult a healthcare provider before starting Modalert, particularly for those with liver concerns, to ensure safe and personalized dosing that minimizes any potential risks to liver health.